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Mar. Drugs 2016, 14(5), 86; doi:10.3390/md14050086

Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity

1
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
2
School of Life Sciences and Biomedical Center, Sun Yat-Sen University, Guangzhou 510275, China
3
Guangdong Food and Drug Vocational College, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 1 March 2016 / Revised: 25 April 2016 / Accepted: 25 April 2016 / Published: 28 April 2016
View Full-Text   |   Download PDF [779 KB, uploaded 28 April 2016]   |  

Abstract

Four new polyketides: nectriacids A–C (1–3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), and macrocarpon C (7) were isolated from the culture of the endophytic fungus Nectria sp. HN001, which was isolated from a fresh branch of the mangrove plant Sonneratia ovata collected from the South China Sea. Their structures were determined by the detailed analysis of NMR and mass spectroscopic data. The absolute configuration of the stereogenic carbons for compound 4 was further assigned by Mosher’s ester method. All of the isolated compounds were tested for their α-glucosidase inhibitory activity by UV absorbance at 405 nm, and new compounds 2 and 3 exhibited potent inhibitory activity with IC50 values of 23.5 and 42.3 μM, respectively, which were more potent than positive control (acarbose, IC50, 815.3 μM). View Full-Text
Keywords: polyketides; α-glucosidase inhibitor; Nectria sp.; pentaene diacid derivatives polyketides; α-glucosidase inhibitor; Nectria sp.; pentaene diacid derivatives
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cui, H.; Liu, Y.; Nie, Y.; Liu, Z.; Chen, S.; Zhang, Z.; Lu, Y.; He, L.; Huang, X.; She, Z. Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity. Mar. Drugs 2016, 14, 86.

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