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Mar. Drugs 2016, 14(4), 64; doi:10.3390/md14040064

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments—LCSNSA EA 2212, Université de la Réunion, 15 Avenue René Cassin, CS 92003, F-97744 Saint-Denis Cedex 9, Ile de la Réunion, France
Ecole Supérieure d′Ingénieurs Réunion Océan Indien—ESIROI, 2 Rue Joseph Wetzell, F-97490 Sainte-Clotilde, Ile de la Réunion, France
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 30 November 2015 / Revised: 12 February 2016 / Accepted: 8 March 2016 / Published: 25 March 2016
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Anthraquinones and their derivatives constitute a large group of quinoid compounds with about 700 molecules described. They are widespread in fungi and their chemical diversity and biological activities recently attracted attention of industries in such fields as pharmaceuticals, clothes dyeing, and food colorants. Their positive and/or negative effect(s) due to the 9,10-anthracenedione structure and its substituents are still not clearly understood and their potential roles or effects on human health are today strongly discussed among scientists. As marine microorganisms recently appeared as producers of an astonishing variety of structurally unique secondary metabolites, they may represent a promising resource for identifying new candidates for therapeutic drugs or daily additives. Within this review, we investigate the present knowledge about the anthraquinones and derivatives listed to date from marine-derived filamentous fungi′s productions. This overview highlights the molecules which have been identified in microorganisms for the first time. The structures and colors of the anthraquinoid compounds come along with the known roles of some molecules in the life of the organisms. Some specific biological activities are also described. This may help to open doors towards innovative natural substances. View Full-Text
Keywords: anthraquinone; marine; fungi; pigment; biological activity; antitumor; antibiotic; cytotoxicity anthraquinone; marine; fungi; pigment; biological activity; antitumor; antibiotic; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fouillaud, M.; Venkatachalam, M.; Girard-Valenciennes, E.; Caro, Y.; Dufossé, L. Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities. Mar. Drugs 2016, 14, 64.

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