Next Article in Journal
A Collaborative Evaluation of LC-MS/MS Based Methods for BMAA Analysis: Soluble Bound BMAA Found to Be an Important Fraction
Previous Article in Journal
Production and Characterization of Antioxidant Properties of Exopolysaccharide(s) from Peanibacillus mucilaginosus TKU032
Article Menu

Export Article

Open AccessFeature PaperReview
Mar. Drugs 2016, 14(3), 42; doi:10.3390/md14030042

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

1,2
and
1,2,*
1
Centre for Marine Sciences, University of Algarve, 8005-139 Faro, Portugal
2
Drug Delivery Laboratory, Centre for Biomedical Research (CBMR), Faculty of Sciences and Technology, University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 14 January 2016 / Revised: 10 February 2016 / Accepted: 15 February 2016 / Published: 25 February 2016
View Full-Text   |   Download PDF [2264 KB, uploaded 25 February 2016]   |  

Abstract

In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae and fucoidan in brown algae. Sulfated polysaccharides have been increasingly studied over the years in the pharmaceutical field, given their potential usefulness in applications such as the design of drug delivery systems. The purpose of this review is to discuss potential applications of these polymers in drug delivery systems, with a focus on carrageenan, ulvan and fucoidan. General information regarding structure, extraction process and physicochemical properties is presented, along with a brief reference to reported biological activities. For each material, specific applications under the scope of drug delivery are described, addressing in privileged manner particulate carriers, as well as hydrogels and beads. A final section approaches the application of sulfated polysaccharides in targeted drug delivery, focusing with particular interest the capacity for macrophage targeting. View Full-Text
Keywords: carrageenan; drug delivery; fucoidan; macrophage targeting; ulvan; sulfated polysaccharides carrageenan; drug delivery; fucoidan; macrophage targeting; ulvan; sulfated polysaccharides
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cunha, L.; Grenha, A. Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications. Mar. Drugs 2016, 14, 42.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top