Next Article in Journal
Lipid Composition of Oil Extracted from Wasted Norway Lobster (Nephrops norvegicus) Heads and Comparison with Oil Extracted from Antarctic Krill (Euphasia superba)
Previous Article in Journal
Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(12), 218; doi:10.3390/md14120218

New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.

1
,
2,3,4
,
5,* , 6,7,8,9,* and 1,5,7,9,10,*
1
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
2
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3
Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine and Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
4
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
5
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
7
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
8
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 24 October 2016 / Revised: 8 November 2016 / Accepted: 16 November 2016 / Published: 26 November 2016
View Full-Text   |   Download PDF [1160 KB, uploaded 26 November 2016]   |  

Abstract

Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. View Full-Text
Keywords: 9,11-secosterol; gorgonian; Pinnigorgia; anti-inflammatory; superoxide anion; elastase 9,11-secosterol; gorgonian; Pinnigorgia; anti-inflammatory; superoxide anion; elastase
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chang, Y.-C.; Hwang, T.-L.; Sheu, J.-H.; Wu, Y.-C.; Sung, P.-J. New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.. Mar. Drugs 2016, 14, 218.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top