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Mar. Drugs 2016, 14(11), 204; doi:10.3390/md14110204

Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

1
GEOMAR Helmholtz Center for Ocean Research Kiel, RD3 Marine Microbiology, Düsternbrooker Weg 20, 24105 Kiel, Germany
2
Ocean College, Zhejiang University, Hangzhou 310058, China
Dedication: This paper is dedicated to Prof. Dr. Dr. h.c. mult. Gerhard Bringmann, a brilliant natural product chemist, a valued partner and a good friend on occasion of his 65th birthday.
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 29 September 2016 / Revised: 24 October 2016 / Accepted: 26 October 2016 / Published: 2 November 2016
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Abstract

The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species. View Full-Text
Keywords: marine fungi; glycogen synthase kinase; acetylcholinesterase; Biscogniauxia mediterranea; deep sea marine fungi; glycogen synthase kinase; acetylcholinesterase; Biscogniauxia mediterranea; deep sea
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MDPI and ACS Style

Wu, B.; Wiese, J.; Schmaljohann, R.; Imhoff, J.F. Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments. Mar. Drugs 2016, 14, 204.

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