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Mar. Drugs 2016, 14(11), 201; doi:10.3390/md14110201

Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China
These authors contributed equally to this work.
Present address: Science and Research Laboratory, Longhua Hosptial, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China.
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Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 29 August 2016 / Revised: 11 October 2016 / Accepted: 12 October 2016 / Published: 28 October 2016
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Abstract

Seven new briarane diterpenoids, gemmacolides AZ–BF (17), were isolated together with eight known analogues (815) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound 8 exhibited a potential antibacterial activity against both Gram-positive bacterium Bacillus megaterium and Gram-negative bacterium Escherichia coli. View Full-Text
Keywords: briarane diterpenoids; biological activity; structure elucidation; gorgonian; Dichotella gemmacea briarane diterpenoids; biological activity; structure elucidation; gorgonian; Dichotella gemmacea
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, C.; La, M.-P.; Tang, H.; Sun, P.; Liu, B.-S.; Zhuang, C.-L.; Yi, Y.-H.; Zhang, W. Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea. Mar. Drugs 2016, 14, 201.

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