Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea
AbstractSeven new briarane diterpenoids, gemmacolides AZ–BF (1–7), were isolated together with eight known analogues (8–15) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound 8 exhibited a potential antibacterial activity against both Gram-positive bacterium Bacillus megaterium and Gram-negative bacterium Escherichia coli. View Full-Text
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Li, C.; La, M.-P.; Tang, H.; Sun, P.; Liu, B.-S.; Zhuang, C.-L.; Yi, Y.-H.; Zhang, W. Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea. Mar. Drugs 2016, 14, 201.
Li C, La M-P, Tang H, Sun P, Liu B-S, Zhuang C-L, Yi Y-H, Zhang W. Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea. Marine Drugs. 2016; 14(11):201.Chicago/Turabian Style
Li, Cui; La, Ming-Ping; Tang, Hua; Sun, Peng; Liu, Bao-Shu; Zhuang, Chun-Lin; Yi, Yang-Hua; Zhang, Wen. 2016. "Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea." Mar. Drugs 14, no. 11: 201.
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