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Mar. Drugs 2016, 14(1), 1; doi:10.3390/md14010001

Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug

1
Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain
2
CIBER de Enfermedades Raras (CIBERER), Málaga E-29071, Spain
Present address: Departamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.
*
Author to whom correspondence should be addressed.
Academic Editor: Keith B. Glaser
Received: 13 October 2015 / Revised: 7 December 2015 / Accepted: 16 December 2015 / Published: 22 December 2015
View Full-Text   |   Download PDF [1124 KB, uploaded 22 December 2015]   |  

Abstract

Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies. View Full-Text
Keywords: (+)-aeroplysinin-1; sponges; marine drugs; inflammation; angiogenesis; cancer (+)-aeroplysinin-1; sponges; marine drugs; inflammation; angiogenesis; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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García-Vilas, J.A.; Martínez-Poveda, B.; Quesada, A.R.; Medina, M.Á. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar. Drugs 2016, 14, 1.

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