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Mar. Drugs 2015, 13(8), 5007-5015; doi:10.3390/md13085007

Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs

Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan
Koyo Chemical Co. Ltd., 1-17 Taiyuji-cho, Kita-ku, Osaka 530-0051, Japan
Author to whom correspondence should be addressed.
Academic Editor: Colin Barrow
Received: 22 February 2015 / Accepted: 24 July 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Marine Functional Food)
View Full-Text   |   Download PDF [390 KB, uploaded 7 August 2015]   |  


N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism. View Full-Text
Keywords: amino acid; cartilage regeneration; dog; N-acetyl-d-glucosamine hydrochloride; TGF-beta amino acid; cartilage regeneration; dog; N-acetyl-d-glucosamine hydrochloride; TGF-beta

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Osaki, T.; Kurozumi, S.; Sato, K.; Terashi, T.; Azuma, K.; Murahata, Y.; Tsuka, T.; Ito, N.; Imagawa, T.; Minami, S.; Okamoto, Y. Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs. Mar. Drugs 2015, 13, 5007-5015.

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