Next Article in Journal
Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction
Previous Article in Journal
A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi
Previous Article in Special Issue
Potential Antiviral Agents from Marine Fungi: An Overview
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(8), 4617-4632; doi:10.3390/md13084617

Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae

1
GEOMAR Helmholtz Centre for Ocean Research Kiel, 24105 Kiel, Germany
2
Ocean College, Zhejiang University, Hangzhou 310058, China
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 11 June 2015 / Revised: 11 July 2015 / Accepted: 16 July 2015 / Published: 27 July 2015
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
View Full-Text   |   Download PDF [504 KB, uploaded 27 July 2015]   |  

Abstract

An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (±0.2) µM and 3.2 (±0.4) μM, respectively, against methicillin-resistant Staphylococcus aureus. View Full-Text
Keywords: marine fungi; lindgomycin; antibiotic; MRSA; marine natural products marine fungi; lindgomycin; antibiotic; MRSA; marine natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wu, B.; Wiese, J.; Labes, A.; Kramer, A.; Schmaljohann, R.; Imhoff, J.F. Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae. Mar. Drugs 2015, 13, 4617-4632.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top