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Mar. Drugs 2015, 13(7), 4452-4469; doi:10.3390/md13074452

Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition

1
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
2
The University of Chinese Academy of Sciences, Beijing 100049, China
3
Qingdao Medical University Affiliated Hospital, Qingdao 266070, China
*
Author to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 30 April 2015 / Revised: 18 June 2015 / Accepted: 7 July 2015 / Published: 17 July 2015
View Full-Text   |   Download PDF [1639 KB, uploaded 17 July 2015]   |  

Abstract

3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol (HPN) is a bromophenol derivative from the marine red alga Rhodomela confervoides. We have previously found that HPN exerted an anti-hyperglycemic property in db/db mouse model. In the present study, we found that HPN could protect HepG2 cells against palmitate (PA)-induced cell death. Data also showed that HPN inhibited cell death mainly by blocking the cell apoptosis. Further studies demonstrated that HPN (especially at 1.0 μM) significantly restored insulin-stimulated tyrosine phosphorylation of IR and IRS1/2, and inhibited the PTP1B expression level in HepG2 cells. Furthermore, the expression of Akt was activated by HPN, and glucose uptake was significantly increased in PA-treated HepG2 cells. Our results suggest that HPN could protect hepatocytes from lipid-induced cell damage and insulin resistance via PTP1B inhibition. Thus, HPN can be considered to have potential for the development of anti-diabetic agent that could protect both hepatic cell mass and function. View Full-Text
Keywords: HPN; palmitate; PTP1B inhibition; anti-cell damage; anti-insulin resistance; HepG2 cell HPN; palmitate; PTP1B inhibition; anti-cell damage; anti-insulin resistance; HepG2 cell
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Luo, J.; Wu, N.; Jiang, B.; Wang, L.; Wang, S.; Li, X.; Wang, B.; Wang, C.; Shi, D. Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition. Mar. Drugs 2015, 13, 4452-4469.

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