Next Article in Journal
1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea
Previous Article in Journal
Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(6), 3531-3549; doi:10.3390/md13063531

Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea

1
Centre of Marine Sciences, University of Algarve, Faro 8005-139, Portugal
2
Department of Chemistry and Biochemistry and Center of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, Campo Grande, Ed. C8, Lisbon 1749-016, Portugal
3
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
4
Department of Chemistry, Faculty of Science, Kuwait University, Safat 13060, Kuwait
5
King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh 11426, Saudi Arabia
6
Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 16 March 2015 / Revised: 18 May 2015 / Accepted: 26 May 2015 / Published: 3 June 2015
View Full-Text   |   Download PDF [432 KB, uploaded 3 June 2015]   |  

Abstract

Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules. Methanol extracts were thus prepared from freeze-dried biomass and screened for different biological activities. Nannochloris sp. SBL1 and Desmochloris sp. SBL3 had the highest radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, and the best copper and iron chelating activities. All species had potent butyrylcholinesterase inhibitory activity (>50%) and mildly inhibited tyrosinase. Picochlorum sp. SBL2 and Nannochloris sp. SBL4 extracts significantly reduced the viability of tumoral (HepG2 and HeLa) cells with lower toxicity against the non-tumoral murine stromal (S17) cells. Nannochloris sp. SBL1 significantly reduced the viability of Leishmania infantum down to 62% (250 µg/mL). Picochlorum sp. SBL2 had the highest total phenolic content, the major phenolic compounds identified being salicylic, coumaric and gallic acids. Neoxanthin, violaxanthin, zeaxanthin, lutein and β-carotene were identified in the extracts of all strains, while canthaxanthin was only identified in Picochlorum sp. SBL2. Taken together, these results strongly suggest that the microalgae included in this work could be used as sources of added-value products that could be used to upgrade the final biomass value. View Full-Text
Keywords: antioxidants; bioprospection; BuChE inhibitors; carotenoids; microalgae; oxidative stress; phenolics antioxidants; bioprospection; BuChE inhibitors; carotenoids; microalgae; oxidative stress; phenolics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pereira, H.; Custódio, L.; Rodrigues, M.J.; de Sousa, C.B.; Oliveira, M.; Barreira, L.; Neng, N.R.; Nogueira, J.M.F.; Alrokayan, S.A.; Mouffouk, F.; Abu-Salah, K.M.; Ben-Hamadou, R.; Varela, J. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar. Drugs 2015, 13, 3531-3549.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top