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Mar. Drugs 2015, 13(6), 3443-3453; doi:10.3390/md13063443

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

1,2,†
,
3,4,†
,
5
,
6,7
,
1,2
,
6
,
5,8,9,10,* and 1,2,6,8,9,*
1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan
4
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
5
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
6
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Division of Cardiology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
8
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 19 April 2015 / Revised: 21 May 2015 / Accepted: 21 May 2015 / Published: 29 May 2015
View Full-Text   |   Download PDF [559 KB, uploaded 29 May 2015]   |  

Abstract

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 μg/mL. View Full-Text
Keywords: Nephthea columnaris; cembrane; octocoral; antiinflammatory; iNOS; COX-2; cytotoxicity Nephthea columnaris; cembrane; octocoral; antiinflammatory; iNOS; COX-2; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hsiao, T.-H.; Sung, C.-S.; Lan, Y.-H.; Wang, Y.-C.; Lu, M.-C.; Wen, Z.-H.; Wu, Y.-C.; Sung, P.-J. New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris. Mar. Drugs 2015, 13, 3443-3453.

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