New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Anesthesiology, Taipei Veterans General Hospital, Taipei 112, Taiwan
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Division of Cardiology, Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 19 April 2015 / Revised: 21 May 2015 / Accepted: 21 May 2015 / Published: 29 May 2015
Two new cembranes, columnariols A (1
) and B (2
), were isolated from the cultured soft coral Nephthea columnaris
. The structures of cembranes 1
were elucidated by spectroscopic methods. In the
anti-inflammatory effects test, cembranes 1
were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1
exhibited moderate cytotoxicity toward LNCaP cells with an IC50
value of 9.80 μg/mL.
This is an open access article distributed under the Creative Commons Attribution License
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MDPI and ACS Style
Hsiao, T.-H.; Sung, C.-S.; Lan, Y.-H.; Wang, Y.-C.; Lu, M.-C.; Wen, Z.-H.; Wu, Y.-C.; Sung, P.-J. New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris. Mar. Drugs 2015, 13, 3443-3453.
Hsiao T-H, Sung C-S, Lan Y-H, Wang Y-C, Lu M-C, Wen Z-H, Wu Y-C, Sung P-J. New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris. Marine Drugs. 2015; 13(6):3443-3453.
Hsiao, Ting-Hsi; Sung, Chun-Sung; Lan, Yu-Hsuan; Wang, Yi-Chen; Lu, Mei-Chin; Wen, Zhi-Hong; Wu, Yang-Chang; Sung, Ping-Jyun. 2015. "New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris." Mar. Drugs 13, no. 6: 3443-3453.
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