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Mar. Drugs 2015, 13(4), 2010-2029; doi:10.3390/md13042010

Marine Natural Products as Breast Cancer Resistance Protein Inhibitors

1
Department of Organic Chemistry, Chemistry School, Faculty of Natural Sciences, Exact and Technology, University of Panama, Panama City P.O. Box 3366, Panama
2
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
3
Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, Panama City P.O. Box 0843-01103, Panama
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 20 February 2015 / Revised: 19 March 2015 / Accepted: 24 March 2015 / Published: 3 April 2015
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Abstract

Breast cancer resistance protein (BCRP) is a protein belonging to the ATP-binding cassette (ABC) transporter superfamily that has clinical relevance due to its multi-drug resistance properties in cancer. BCRP can be associated with clinical cancer drug resistance, in particular acute myelogenous or acute lymphocytic leukemias. The overexpression of BCRP contributes to the resistance of several chemotherapeutic drugs, such as topotecan, methotrexate, mitoxantrone, doxorubicin and daunorubicin. The Food and Drugs Administration has already recognized that BCRP is clinically one of the most important drug transporters, mainly because it leads to a reduction of clinical efficacy of various anticancer drugs through its ATP-dependent drug efflux pump function as well as its apparent participation in drug resistance. This review article aims to summarize the different research findings on marine natural products with BCRP inhibiting activity. In this sense, the potential modulation of physiological targets of BCRP by natural or synthetic compounds offers a great possibility for the discovery of new drugs and valuable research tools to recognize the function of the complex ABC-transporters. View Full-Text
Keywords: marine natural products; ABC transporters; breast cancer resistance protein (BCRP); multidrug resistance (MDR) marine natural products; ABC transporters; breast cancer resistance protein (BCRP); multidrug resistance (MDR)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cherigo, L.; Lopez, D.; Martinez-Luis, S. Marine Natural Products as Breast Cancer Resistance Protein Inhibitors. Mar. Drugs 2015, 13, 2010-2029.

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