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Mar. Drugs 2015, 13(4), 1882-1900; doi:10.3390/md13041882

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

1
Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 20401, Taiwan
2
Graduate Institute of Clinical Medicine Sciences, Chang Gung University, Taoyuan 33302, Taiwan
3
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan
4
Department of Life Science, Chinese Culture University, Taipei 11114, Taiwan
5
Aquatic Technology Laboratories, Agricultural Technology Research Institute, Hsinchu 30093, Taiwan
6
Institute of Biomedical Nutrition, Hung Kuang University, Taichung 43302, Taiwan
7
Holistic Education Center, Mackay Medical College, New Taipei City 25245, Taiwan
8
Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan
9
Laboratory for Epidemiology, Department and graduate institute of health care management, Chang Gung University, Taoyuan 33302, Taiwan
10
Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 12 February 2015 / Revised: 26 March 2015 / Accepted: 27 March 2015 / Published: 3 April 2015
(This article belongs to the Collection Marine Polysaccharides)
View Full-Text   |   Download PDF [883 KB, uploaded 3 April 2015]   |  

Abstract

Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs. View Full-Text
Keywords: fucoidan; sulfated polysaccharide; lung carcinoma; metastasis; cachexia; chemo-preventative agent fucoidan; sulfated polysaccharide; lung carcinoma; metastasis; cachexia; chemo-preventative agent
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, T.-H.; Chiu, Y.-H.; Chan, Y.-L.; Chiu, Y.-H.; Wang, H.; Huang, K.-C.; Li, T.-L.; Hsu, K.-H.; Wu, C.-J. Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice. Mar. Drugs 2015, 13, 1882-1900.

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