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Mar. Drugs 2015, 13(3), 1290-1303; doi:10.3390/md13031290

Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
College of Pharmacy, Seoul National University, Seoul 151-742, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Kellie L. Tuck
Received: 1 December 2014 / Revised: 2 March 2015 / Accepted: 2 March 2015 / Published: 12 March 2015
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
View Full-Text   |   Download PDF [547 KB, uploaded 12 March 2015]   |  

Abstract

Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition. View Full-Text
Keywords: lumazine; peptide; Aspergillus terreus; insulin sensitivity lumazine; peptide; Aspergillus terreus; insulin sensitivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

You, M.; Liao, L.; Hong, S.H.; Park, W.; Kwon, D.I.; Lee, J.; Noh, M.; Oh, D.-C.; Oh, K.-B.; Shin, J. Lumazine Peptides from the Marine-Derived Fungus Aspergillus terreus. Mar. Drugs 2015, 13, 1290-1303.

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