Next Article in Journal
Protective Effect of Chitin Urocanate Nanofibers against Ultraviolet Radiation
Previous Article in Journal
Generation of Internal-Image Functional Aptamers of Okadaic Acid via Magnetic-Bead SELEX
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(12), 7446-7462; doi:10.3390/md13127075

Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis

1
Inserm, UMR-S765, 75006 Paris, France
2
Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
3
Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France
4
Inserm, UMR-S970, 75015 Paris, France
5
Plateforme P3S, Sorbonne Universités, 75013 Paris, France
6
Inserm, UMR-S1140, 75006 Paris, France
7
AP-HP, Hôpital Européen Georges Pompidou, 75015 Paris, France
8
IFREMER, Route de l’Ile d’Yeu, 44300 Nantes, France
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 20 November 2015 / Revised: 10 December 2015 / Accepted: 11 December 2015 / Published: 18 December 2015
View Full-Text   |   Download PDF [1433 KB, uploaded 18 December 2015]   |  

Abstract

Low-molecular-weight fucoidan (LMWF) is a sulfated polysaccharide extracted from brown seaweed that presents antithrombotic and pro-angiogenic properties. However, its mechanism of action is not well-characterized. Here, we studied the effects of LMWF on cell signaling and whole genome expression in human umbilical vein endothelial cells and endothelial colony forming cells. We observed that LMWF and vascular endothelial growth factor had synergistic effects on cell signaling, and more interestingly that LMWF by itself, in the absence of other growth factors, was able to trigger the activation of the PI3K/AKT pathway, which plays a crucial role in angiogenesis and vasculogenesis. We also observed that the effects of LMWF on cell migration were PI3K/AKT-dependent and that LMWF modulated the expression of genes involved at different levels of the neovessel formation process, such as cell migration and cytoskeleton organization, cell mobilization and homing. This provides a better understanding of LMWF’s mechanism of action and confirms that it could be an interesting therapeutic approach for vascular repair. View Full-Text
Keywords: fucoidan; angiogenesis; vasculogenesis; migration; signaling; transcriptomics fucoidan; angiogenesis; vasculogenesis; migration; signaling; transcriptomics
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bouvard, C.; Galy-Fauroux, I.; Grelac, F.; Carpentier, W.; Lokajczyk, A.; Gandrille, S.; Colliec-Jouault, S.; Fischer, A.-M.; Helley, D. Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis. Mar. Drugs 2015, 13, 7446-7462.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top