Next Article in Journal
The 9th European Conference on Marine Natural Products
Previous Article in Journal
Influence of Temperature on Growth and Production of Pectenotoxin-2 by a Monoclonal Culture of Dinophysis caudata
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(12), 7138-7149; doi:10.3390/md13127060

Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

1,2,†
,
3,†
,
1,4
,
5,6
,
2,7
,
2,4
,
3,8,9,10,* , 1,4,* and 1,2,3,10,11,*
1
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
4
Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University & Academia Sinica, Kaohsiung 804, Taiwan
5
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
6
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
7
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
9
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
11
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 8 November 2015 / Revised: 20 November 2015 / Accepted: 25 November 2015 / Published: 3 December 2015
View Full-Text   |   Download PDF [1103 KB, uploaded 3 December 2015]   |  

Abstract

Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (15), were isolated from the octocoral Briareum sp. The structures of briaranes 15 were elucidated by spectroscopic methods. Briarenolides U–Y (15) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. View Full-Text
Keywords: Briareum; briarane; octocoral; anti-inflammatory; iNOS; COX-2 Briareum; briarane; octocoral; anti-inflammatory; iNOS; COX-2
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Su, Y.-D.; Wu, T.-Y.; Wen, Z.-H.; Su, C.-C.; Chen, Y.-H.; Chang, Y.-C.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Mar. Drugs 2015, 13, 7138-7149.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top