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Mar. Drugs 2015, 13(12), 7138-7149; doi:10.3390/md13127060

Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

3,8,9,10,* , 1,4,* and 1,2,3,10,11,*
Department of Marine Biotechnology & Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University & Academia Sinica, Kaohsiung 804, Taiwan
Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 8 November 2015 / Revised: 20 November 2015 / Accepted: 25 November 2015 / Published: 3 December 2015
View Full-Text   |   Download PDF [1103 KB, uploaded 3 December 2015]   |  


Five new 13,14-epoxybriarane diterpenoids, briarenolides U–Y (15), were isolated from the octocoral Briareum sp. The structures of briaranes 15 were elucidated by spectroscopic methods. Briarenolides U–Y (15) were found to significantly inhibit the expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. View Full-Text
Keywords: Briareum; briarane; octocoral; anti-inflammatory; iNOS; COX-2 Briareum; briarane; octocoral; anti-inflammatory; iNOS; COX-2

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Su, Y.-D.; Wu, T.-Y.; Wen, Z.-H.; Su, C.-C.; Chen, Y.-H.; Chang, Y.-C.; Wu, Y.-C.; Sheu, J.-H.; Sung, P.-J. Briarenolides U–Y, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae). Mar. Drugs 2015, 13, 7138-7149.

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