Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica
AbstractIn the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Hemimycale arabica. The antimicrobial fraction of an organic extract of the sponge afforded two new hydantoin alkaloids, hemimycalins A and B (2 and 3), together with the previously reported compound (Z)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione (1). The structures of the compounds were determined by extensive 1D and 2D NMR (COSY, HSQC and HMBC) studies and high-resolution mass spectral determinations. Hemimycalins A (2) and B (3) represent the first examples of the natural N-alkylated hydantoins from the sponge Hemimycale arabica. Compounds 1–3 displayed variable antimicrobial activities against E. coli, S. aureus, and C. albicans. In addition, compound 1 displayed moderate antiproliferative activity against the human cervical carcinoma (HeLa) cell line. These findings provide further insight into the chemical diversity as well as the biological activity of this class of compounds. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Youssef, D.T.A.; Shaala, L.A.; Alshali, K.Z. Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica. Mar. Drugs 2015, 13, 6609-6619.
Youssef DTA, Shaala LA, Alshali KZ. Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica. Marine Drugs. 2015; 13(11):6609-6619.Chicago/Turabian Style
Youssef, Diaa T.A.; Shaala, Lamiaa A.; Alshali, Khalid Z. 2015. "Bioactive Hydantoin Alkaloids from the Red Sea Marine Sponge Hemimycale arabica." Mar. Drugs 13, no. 11: 6609-6619.