Next Article in Journal
Analysis of Mycosporine-Like Amino Acids in Selected Algae and Cyanobacteria by Hydrophilic Interaction Liquid Chromatography and a Novel MAA from the Red Alga Catenella repens
Previous Article in Journal
Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(10), 6274-6290; doi:10.3390/md13106274

Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

1
Department of Chemistry, Texas A&M University, College Station, TX 77843, USA
2
Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA
3
Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 13 August 2015 / Revised: 25 September 2015 / Accepted: 25 September 2015 / Published: 9 October 2015
View Full-Text   |   Download PDF [1011 KB, uploaded 9 October 2015]   |  

Abstract

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue. View Full-Text
Keywords: macrolactone; polyketide; cyanobacteria; chemotaxis; cell cycle macrolactone; polyketide; cyanobacteria; chemotaxis; cell cycle
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mori, S.; Williams, H.; Cagle, D.; Karanovich, K.; Horgen, F.D.; III, R.S.; Watanabe, C.M.H. Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity. Mar. Drugs 2015, 13, 6274-6290.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top