Next Article in Journal
Characterization of ACE Inhibitory Peptides from Mactra veneriformis Hydrolysate by Nano-Liquid Chromatography Electrospray Ionization Mass Spectrometry (Nano-LC-ESI-MS) and Molecular Docking
Previous Article in Journal
Oleosome-Associated Protein of the Oleaginous Diatom Fistulifera solaris Contains an Endoplasmic Reticulum-Targeting Signal Sequence
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2014, 12(7), 3904-3916; https://doi.org/10.3390/md12073904

Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
2
Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, Geb.26.23, 40225 Düsseldorf, Germany
3
Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
Received: 11 April 2014 / Revised: 20 May 2014 / Accepted: 5 June 2014 / Published: 30 June 2014
View Full-Text   |   Download PDF [570 KB, uploaded 24 February 2015]   |  

Abstract

Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (16), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the extensive HRESIMS and NMR spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of punctaporonins H–I (12). The isolated compounds were evaluated for antihyperlipidemic, cytotoxic and antimicrobial activities, and punctaporonin K (4) exhibited potent effects to reduce the triglycerides and total cholesterol in the intracellular levels. View Full-Text
Keywords: sponge-associated fungus; Hansfordia sinuosae; punctaporonins H–M; structural elucidation; lowering lipid accumulation sponge-associated fungus; Hansfordia sinuosae; punctaporonins H–M; structural elucidation; lowering lipid accumulation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Wu, Z.; Liu, D.; Proksch, P.; Guo, P.; Lin, W. Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae. Mar. Drugs 2014, 12, 3904-3916.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top