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Mar. Drugs 2014, 12(7), 3904-3916; doi:10.3390/md12073904

Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
2
Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, Geb.26.23, 40225 Düsseldorf, Germany
3
Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
Received: 11 April 2014 / Revised: 20 May 2014 / Accepted: 5 June 2014 / Published: 30 June 2014
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Abstract

Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (16), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the extensive HRESIMS and NMR spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of punctaporonins H–I (12). The isolated compounds were evaluated for antihyperlipidemic, cytotoxic and antimicrobial activities, and punctaporonin K (4) exhibited potent effects to reduce the triglycerides and total cholesterol in the intracellular levels. View Full-Text
Keywords: sponge-associated fungus; Hansfordia sinuosae; punctaporonins H–M; structural elucidation; lowering lipid accumulation sponge-associated fungus; Hansfordia sinuosae; punctaporonins H–M; structural elucidation; lowering lipid accumulation
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Wu, Z.; Liu, D.; Proksch, P.; Guo, P.; Lin, W. Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae. Mar. Drugs 2014, 12, 3904-3916.

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