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Mar. Drugs 2014, 12(6), 3754-3769; doi:10.3390/md12063754

Amino Alcohols from the Ascidian Pseudodistoma sp.

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea
*
Authors to whom correspondence should be addressed.
Received: 9 May 2014 / Revised: 30 May 2014 / Accepted: 30 May 2014 / Published: 24 June 2014
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Abstract

Seven new amino alcohol compounds, pseudoaminols A–G (17), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase. View Full-Text
Keywords: amino alcohols; pseudoaminols; Pseudodistoma sp.; stereochemistry; bioactivities amino alcohols; pseudoaminols; Pseudodistoma sp.; stereochemistry; bioactivities
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MDPI and ACS Style

Won, T.H.; You, M.; Lee, S.-H.; Rho, B.J.; Oh, D.-C.; Oh, K.-B.; Shin, J. Amino Alcohols from the Ascidian Pseudodistoma sp.. Mar. Drugs 2014, 12, 3754-3769.

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