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Mar. Drugs 2014, 12(6), 3477-3486; doi:10.3390/md12063477

Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata

1
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
2
Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan
3
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
4
Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
Received: 2 April 2014 / Revised: 9 May 2014 / Accepted: 12 May 2014 / Published: 5 June 2014
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Abstract

Two novel diterpenoids, cespitulones A (1) and B (2), were isolated from extracts of the soft coral Cespitularia taeniata. Both compounds possess an unprecedented bicyclo [10.3.1] ring system with C-C bond connections between C-10 and C-20, and between C-20 and C-11. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 1 exhibited significant cytotoxicity against human medulloblastoma and colon adenocarcinoma cancer cells. View Full-Text
Keywords: Cespitularia taeniata; diterpenoid; cespitulone; cytotoxicity Cespitularia taeniata; diterpenoid; cespitulone; cytotoxicity
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Lin, Y.-C.; Wang, S.-S.; Chen, C.-H.; Kuo, Y.-H.; Shen, Y.-C. Cespitulones A and B, Cytotoxic Diterpenoids of a New Structure Class from the Soft Coral Cespitularia taeniata. Mar. Drugs 2014, 12, 3477-3486.

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