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Mar. Drugs 2014, 12(2), 589-600; doi:10.3390/md12020589
Article

Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea

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 and 2,*
1 Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 2 Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, China 3 Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA
* Author to whom correspondence should be addressed.
Received: 12 December 2013 / Revised: 13 January 2014 / Accepted: 15 January 2014 / Published: 27 January 2014
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Abstract

Four new briarane diterpenoids, junceellolides M–P (14), were isolated together with seven known analogs (511) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 13 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.
Keywords: Junceella gemmacea; briarane; diterpenoid; junceellolide Junceella gemmacea; briarane; diterpenoid; junceellolide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhou, W.; Li, J.; E, H.-C.; Liu, B.-S.; Tang, H.; Gerwick, W.H.; Hua, H.-M.; Zhang, W. Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea. Mar. Drugs 2014, 12, 589-600.

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