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Chinese Marine Materia Medica. By Huashi Guan and Shuguang Wang. Shanghai Scientific and Technical Publishers, China Ocean Press, and Chemical Industry Press: Shanghai, Beijing, China, 2009; Hardback, 7064 pp; ¥ 2920; ISBN 978-7-5323-9958-1/R•2707; ISBN 978-7-5323-9973-4/R•2708; ISBN 978-7-1220-6012-9
Mar. Drugs 2014, 12(1), 196-213; doi:10.3390/md12010196
Article

Inhibitory Effect of Dihydroaustrasulfone Alcohol on the Migration of Human Non-Small Cell Lung Carcinoma A549 Cells and the Antitumor Effect on a Lewis Lung Carcinoma-Bearing Tumor Model in C57BL/6J Mice

1,2,3
, 4,5
, 5
, 6, 7,*  and 5,*
1 Graduate Institute of Clinical Medical Science, China Medical University, Taichung 404, Taiwan 2 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan 3 School of Medicine, China Medical University, Taichung 404, Taiwan 4 School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan 5 College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei City 110, Taiwan 6 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan 7 Division of Chest Surgery and Cancer Center, Department of Surgery, China Medical University Hospital, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 13 November 2013 / Revised: 14 December 2013 / Accepted: 16 December 2013 / Published: 9 January 2014
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Abstract

There are many major causes of cancer death, including metastasis of cancer. Dihydroaustrasulfone alcohol, which is isolated from marine coral, has shown antioxidant activity, but has not been reported to have an anti-cancer effect. We first discovered that dihydroaustrasulfone alcohol provided a concentration-dependent inhibitory effect on the migration and motility of human non-small cell lung carcinoma (NSCLC) A549 cells by trans-well and wound healing assays. The results of a zymography assay and Western blot showed that dihydroaustrasulfone alcohol suppressed the activities and protein expression of matrix metalloproteinase (MMP)-2 and MMP-9. Further investigation revealed that dihydroaustrasulfone alcohol suppressed the phosphorylation of ERK1/2, p38, and JNK1/2. Dihydroaustrasulfone alcohol also suppressed the expression of PI3K and the phosphorylation of Akt. Furthermore, dihydroaustrasulfone alcohol markedly inhibited tumor growth in Lewis lung cancer (LLC)-bearing mice. We concluded that dihydroaustrasulfone alcohol is a new pure compound with anti-migration and anti-tumor growth activity in lung cancer and might be applied to clinical treatment in the future.
Keywords: non-small cell lung cancer; migration; tumor; matrix metalloproteinase; marine origin non-small cell lung cancer; migration; tumor; matrix metalloproteinase; marine origin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, S.-C.; Chien, Y.-C.; Pan, C.-H.; Sheu, J.-H.; Chen, C.-Y.; Wu, C.-H. Inhibitory Effect of Dihydroaustrasulfone Alcohol on the Migration of Human Non-Small Cell Lung Carcinoma A549 Cells and the Antitumor Effect on a Lewis Lung Carcinoma-Bearing Tumor Model in C57BL/6J Mice. Mar. Drugs 2014, 12, 196-213.

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