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Secondary Metabolites from the Soft Coral Sinularia arborea
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Author to whom correspondence should be addressed.
Received: 10 July 2013; in revised form: 16 August 2013 / Accepted: 26 August 2013 / Published: 3 September 2013
Abstract: Previous studies on the chemical constituents of soft corals belonging to the genus Sinularia have led to the isolation of a number of interesting secondary metabolites and some of these were found to possess extensive bioactivities [1–3]. Continuation investigation on the chemical constituents of the marine invertebrates collected off the waters of Taiwan, two new cembrane-type diterpenoids, arbolides A (1) and B (2), and a known steroid, crassarosterol A (3) , were isolated from the soft coral Sinularia arborea (family Alcyonacea) (Figure 1). In this paper, we describe the isolation, structure determination and cytotoxicity of compounds 1–3.
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Chen, K.-H.; Dai, C.-F.; Lu, M.-C.; Li, J.-J.; Chen, J.-J.; Chang, Y.-C.; Su, Y.-D.; Wang, W.-H.; Sung, P.-J. Secondary Metabolites from the Soft Coral Sinularia arborea. Mar. Drugs 2013, 11, 3372-3380.
Chen K-H, Dai C-F, Lu M-C, Li J-J, Chen J-J, Chang Y-C, Su Y-D, Wang W-H, Sung P-J. Secondary Metabolites from the Soft Coral Sinularia arborea. Marine Drugs. 2013; 11(9):3372-3380.
Chen, Kuan-Hua; Dai, Chang-Feng; Lu, Mei-Chin; Li, Jan-Jung; Chen, Jih-Jung; Chang, Yu-Chia; Su, Yin-Di; Wang, Wei-Hsien; Sung, Ping-Jyun. 2013. "Secondary Metabolites from the Soft Coral Sinularia arborea." Mar. Drugs 11, no. 9: 3372-3380.