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Mar. Drugs 2013, 11(9), 3309-3323; doi:10.3390/md11093309
Article

Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

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 and *
Kiel Center for Marine Natural Products KiWiZ, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, Kiel 24106, Germany
* Author to whom correspondence should be addressed.
Received: 24 July 2013 / Revised: 16 August 2013 / Accepted: 21 August 2013 / Published: 29 August 2013
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Abstract

Bioactive compounds were detected in crude extracts of the fungus, Calcarisporium sp. KF525, which was isolated from German Wadden Sea water samples. Purification of the metabolites from the extracts yielded the five known polyesters, 15G256α, α-2, β, β-2 and π (15), and five new derivatives thereof, named calcarides A–E (610). The chemical structures of the isolated compounds were elucidated on the basis of one- and two-dimensional NMR spectroscopy supported by UV and HRESIMS data. The compounds exhibited inhibitory activities against Staphylococcus epidermidis, Xanthomonas campestris and Propionibacterium acnes. As the antibacterial activities were highly specific with regard to compound and test strain, a tight structure-activity relationship is assumed.
Keywords: fungal natural products; Calcarisporium sp.; calcarides A–E; 15G256 components; macrocyclic and linear polyesters; antibacterial activities; antibiotic; marine natural products fungal natural products; Calcarisporium sp.; calcarides A–E; 15G256 components; macrocyclic and linear polyesters; antibacterial activities; antibiotic; marine natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Silber, J.; Ohlendorf, B.; Labes, A.; Erhard, A.; Imhoff, J.F. Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain. Mar. Drugs 2013, 11, 3309-3323.

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