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Mar. Drugs 2013, 11(4), 1104-1112; doi:10.3390/md11041104

Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece Deceased on 12 May 2010.
* Author to whom correspondence should be addressed.
Received: 25 February 2013 / Revised: 13 March 2013 / Accepted: 19 March 2013 / Published: 2 April 2013
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Three new dolastane diterpenes (13) and five previously reported perhydroazulenes were isolated from the organic extracts of the brown alga Dilophus spiralis. The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on extensive analyses of their spectroscopic data, whereas the absolute configuration of metabolite 2 was determined through its chemical conversion to a previously isolated compound of known configuration.
Keywords: Dilophus spiralis; dolastanes; structure elucidation Dilophus spiralis; dolastanes; structure elucidation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Ioannou, E.; Vagias, C.; Roussis, V. Isolation and Structure Elucidation of Three New Dolastanes from the Brown Alga Dilophus spiralis. Mar. Drugs 2013, 11, 1104-1112.

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