Mar. Drugs 2013, 11(12), 5089-5099; doi:10.3390/md11125089
Article

Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue

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Received: 22 October 2013; in revised form: 13 November 2013 / Accepted: 3 December 2013 / Published: 16 December 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases.
Keywords: Ecteinascidia turbinata; halomadurones; Actinomadura; nuclear factor E2-related factor antioxidant response element
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MDPI and ACS Style

Wyche, T.P.; Standiford, M.; Hou, Y.; Braun, D.; Johnson, D.A.; Johnson, J.A.; Bugni, T.S. Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue. Mar. Drugs 2013, 11, 5089-5099.

AMA Style

Wyche TP, Standiford M, Hou Y, Braun D, Johnson DA, Johnson JA, Bugni TS. Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue. Marine Drugs. 2013; 11(12):5089-5099.

Chicago/Turabian Style

Wyche, Thomas P.; Standiford, Miranda; Hou, Yanpeng; Braun, Doug; Johnson, Delinda A.; Johnson, Jeffrey A.; Bugni, Tim S. 2013. "Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue." Mar. Drugs 11, no. 12: 5089-5099.

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