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Mar. Drugs 2013, 11(12), 5089-5099; doi:10.3390/md11125089

Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue

Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA
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Received: 22 October 2013 / Revised: 13 November 2013 / Accepted: 3 December 2013 / Published: 16 December 2013
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Abstract

Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases.
Keywords: Ecteinascidia turbinata; halomadurones; Actinomadura; nuclear factor E2-related factor antioxidant response element Ecteinascidia turbinata; halomadurones; Actinomadura; nuclear factor E2-related factor antioxidant response element
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wyche, T.P.; Standiford, M.; Hou, Y.; Braun, D.; Johnson, D.A.; Johnson, J.A.; Bugni, T.S. Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue. Mar. Drugs 2013, 11, 5089-5099.

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