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Mar. Drugs 2013, 11(12), 5089-5099; doi:10.3390/md11125089
Article

Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue

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Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA
* Author to whom correspondence should be addressed.
Received: 22 October 2013 / Revised: 13 November 2013 / Accepted: 3 December 2013 / Published: 16 December 2013
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Abstract

Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases.
Keywords: Ecteinascidia turbinata; halomadurones; Actinomadura; nuclear factor E2-related factor antioxidant response element Ecteinascidia turbinata; halomadurones; Actinomadura; nuclear factor E2-related factor antioxidant response element
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wyche, T.P.; Standiford, M.; Hou, Y.; Braun, D.; Johnson, D.A.; Johnson, J.A.; Bugni, T.S. Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue. Mar. Drugs 2013, 11, 5089-5099.

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