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Mar. Drugs 2013, 11(1), 136-145; doi:10.3390/md11010136
Article

Steroidal Carboxylic Acids from Soft Coral Paraminabea acronocephala

1,2,3
,
4
,
1,5
 and
1,5,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan 3 China Medical University, Taichung 40402, Taiwan 4 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
* Author to whom correspondence should be addressed.
Received: 28 November 2012 / Revised: 28 December 2012 / Accepted: 31 December 2012 / Published: 11 January 2013
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Abstract

Three new steroidal carboxylic acids, paraminabic acids A–C (13) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC50 values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.
Keywords: Paraminabea acronocephala; paraminabic acid; soft coral; cytotoxicity; anti-inflammatory activity Paraminabea acronocephala; paraminabic acid; soft coral; cytotoxicity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chao, C.-H.; Wu, Y.-C.; Wen, Z.-H.; Sheu, J.-H. Steroidal Carboxylic Acids from Soft Coral Paraminabea acronocephala . Mar. Drugs 2013, 11, 136-145.

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