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Mar. Drugs 2012, 10(9), 2023-2032; doi:10.3390/md10092023

Article

New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.

Bin Yang ^1,2 , Xuefeng Zhou ^1,2 , Hui Huang ¹ , Xian-Wen Yang ^1,2 , Juan Liu ^1,2 , Xiuping Lin ^1,2 , Xiubao Li ¹ , Yan Peng ^1,2  and Yonghong Liu ^1,2,*

¹ Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China ² Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

* Author to whom correspondence should be addressed.

Received: 12 July 2012; in revised form: 16 August 2012 / Accepted: 7 September 2012 / Published: 18 September 2012

Download PDF Full-Text [598 KB, uploaded 18 September 2012 13:57 CEST]

Abstract: Five new cembrane diterpenoids, named sinuflexibilins A–E (1–5), along with nine other known diterpenoids (6–14), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.

Keywords: Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor

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