Next Article in Journal
The Antiangiogenic Compound Aeroplysinin-1 Induces Apoptosis in Endothelial Cells by Activating the Mitochondrial Pathway
Previous Article in Journal
Antiproliferative Activity of Fucan Nanogel
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2012, 10(9), 2023-2032; doi:10.3390/md10092023

New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.

1
Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
*
Author to whom correspondence should be addressed.
Received: 12 July 2012 / Revised: 16 August 2012 / Accepted: 7 September 2012 / Published: 18 September 2012
View Full-Text   |   Download PDF [598 KB, uploaded 24 February 2015]   |  

Abstract

Five new cembrane diterpenoids, named sinuflexibilins A–E (15), along with nine other known diterpenoids (614), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.
Keywords: Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yang, B.; Zhou, X.; Huang, H.; Yang, X.-W.; Liu, J.; Lin, X.; Li, X.; Peng, Y.; Liu, Y. New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.. Mar. Drugs 2012, 10, 2023-2032.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top