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Mar. Drugs 2012, 10(9), 2023-2032; doi:10.3390/md10092023
Article

New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.

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1 Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2 Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
* Author to whom correspondence should be addressed.
Received: 12 July 2012 / Revised: 16 August 2012 / Accepted: 7 September 2012 / Published: 18 September 2012
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Abstract

Five new cembrane diterpenoids, named sinuflexibilins A–E (15), along with nine other known diterpenoids (614), have been isolated from the organic extract of a Hainan soft coral Sinularia sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of related metabolites. Compound 13, flexibilide, exhibited significant inhibitory activity of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay.
Keywords: Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor Sinularia sp.; cembrane diterpenoids; NF-κB inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, B.; Zhou, X.; Huang, H.; Yang, X.-W.; Liu, J.; Lin, X.; Li, X.; Peng, Y.; Liu, Y. New Cembrane Diterpenoids from a Hainan Soft Coral Sinularia sp.. Mar. Drugs 2012, 10, 2023-2032.

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