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Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China
College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf 40225, Germany
* Author to whom correspondence should be addressed.
Received: 3 July 2012; in revised form: 10 August 2012 / Accepted: 4 September 2012 / Published: 17 September 2012
Abstract: Four new meroterpenes, guignardones F–I (1–4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1–6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.
Keywords: marine endophyte; Scyphiphora hydrophyllacea; meroterpenes; Guignardia sp.; MRSA; Staphylococcus aureus
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Mei, W.-L.; Zheng, B.; Zhao, Y.-X.; Zhong, H.-M.; Chen, X.-L.; Zeng, Y.-B.; Dong, W.-H.; Huang, J.-L.; Proksch, P.; Dai, H.-F. Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea. Mar. Drugs 2012, 10, 1993-2001.
Mei W-L, Zheng B, Zhao Y-X, Zhong H-M, Chen X-L, Zeng Y-B, Dong W-H, Huang J-L, Proksch P, Dai H-F. Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea. Marine Drugs. 2012; 10(9):1993-2001.
Mei, Wen-Li; Zheng, Bo; Zhao, You-Xing; Zhong, Hui-Ming; Chen, Xun-Li Wu; Zeng, Yan-Bo; Dong, Wen-Hua; Huang, Jiu-Li; Proksch, Peter; Dai, Hao-Fu. 2012. "Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea." Mar. Drugs 10, no. 9: 1993-2001.