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Mar. Drugs 2012, 10(9), 1993-2001; doi:10.3390/md10091993
Article

Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea

1,†
, 1,2,†
, 1
, 2
, 1
, 1
, 1
, 1
, 3
 and 1,*
1 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China 2 College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China 3 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf 40225, Germany
* Author to whom correspondence should be addressed.
Received: 3 July 2012 / Revised: 10 August 2012 / Accepted: 4 September 2012 / Published: 17 September 2012
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Abstract

Four new meroterpenes, guignardones F–I (14), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 16 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.
Keywords: marine endophyte; Scyphiphora hydrophyllacea; meroterpenes; Guignardia sp.; MRSA; Staphylococcus aureus marine endophyte; Scyphiphora hydrophyllacea; meroterpenes; Guignardia sp.; MRSA; Staphylococcus aureus
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Mei, W.-L.; Zheng, B.; Zhao, Y.-X.; Zhong, H.-M.; Chen, X.-L.; Zeng, Y.-B.; Dong, W.-H.; Huang, J.-L.; Proksch, P.; Dai, H.-F. Meroterpenes from Endophytic Fungus A1 of Mangrove Plant Scyphiphora hydrophyllacea. Mar. Drugs 2012, 10, 1993-2001.

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