Mar. Drugs 2012, 10(4), 932-952; doi:10.3390/md10040932
Article

Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells

1,2email, 1,2email, 3email, 1,2email, 2,4,5email, 1,2email, 2,4,5email, 1,2email, 2,4,5email, 2,4,5,* email and 1,2,* email
1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, 135 Xingang West Road, Guangzhou 510275, China 2 Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism, Bureau of Education, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China 3 School of Chemistry and Environment, South China Normal University, 348 West Outer Ring Road, Guangzhou 510006, China 4 Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China 5 Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
* Authors to whom correspondence should be addressed.
Received: 23 February 2012; in revised form: 10 April 2012 / Accepted: 12 April 2012 / Published: 24 April 2012
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Abstract: A series of new derivatives (529) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data.
Keywords: bostrycin; synthesis; antitumor; derivatives; structure-activity relationship

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MDPI and ACS Style

Chen, H.; Zhong, L.; Long, Y.; Li, J.; Wu, J.; Liu, L.; Chen, S.; Lin, Y.; Li, M.; Zhu, X.; She, Z. Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells. Mar. Drugs 2012, 10, 932-952.

AMA Style

Chen H, Zhong L, Long Y, Li J, Wu J, Liu L, Chen S, Lin Y, Li M, Zhu X, She Z. Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells. Marine Drugs. 2012; 10(4):932-952.

Chicago/Turabian Style

Chen, Hong; Zhong, Lili; Long, Yuhua; Li, Jia; Wu, Jueheng; Liu, Lan; Chen, Shengping; Lin, Yongcheng; Li, Mengfeng; Zhu, Xun; She, Zhigang. 2012. "Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells." Mar. Drugs 10, no. 4: 932-952.

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