Mar. Drugs 2012, 10(4), 932-952; doi:10.3390/md10040932
Article

Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells

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Received: 23 February 2012; in revised form: 10 April 2012 / Accepted: 12 April 2012 / Published: 24 April 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of new derivatives (529) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data.
Keywords: bostrycin; synthesis; antitumor; derivatives; structure-activity relationship
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MDPI and ACS Style

Chen, H.; Zhong, L.; Long, Y.; Li, J.; Wu, J.; Liu, L.; Chen, S.; Lin, Y.; Li, M.; Zhu, X.; She, Z. Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells. Mar. Drugs 2012, 10, 932-952.

AMA Style

Chen H, Zhong L, Long Y, Li J, Wu J, Liu L, Chen S, Lin Y, Li M, Zhu X, She Z. Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells. Marine Drugs. 2012; 10(4):932-952.

Chicago/Turabian Style

Chen, Hong; Zhong, Lili; Long, Yuhua; Li, Jia; Wu, Jueheng; Liu, Lan; Chen, Shengping; Lin, Yongcheng; Li, Mengfeng; Zhu, Xun; She, Zhigang. 2012. "Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells." Mar. Drugs 10, no. 4: 932-952.


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