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The Alkaloid Ageladine A, Originally Isolated from Marine Sponges, Used for pH-Sensitive Imaging of Transparent Marine Animals
Mar. Drugs 2012, 10(1), 234-241; doi:10.3390/md10010234
Short Note

Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.

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Received: 20 November 2011; in revised form: 19 December 2011 / Accepted: 22 December 2011 / Published: 19 January 2012
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Abstract: Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (−)-sydonol (2), (−)-sydonic acid (3), and (−)-5-(hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Four of them (14) are optically active compounds. Their structures and absolute configurations were elucidated by using NMR spectroscopic techniques and mass spectrometric analysis, and by comparing their optical rotations with those related known analogues. Compounds 15 showed selective antibacterial activity against eight bacterial strains with the MIC (minimum inhibiting concentrations) values between 1.25 and 20.0 µM. The cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were also examined.
Keywords: bisabolane-type sesquiterpenoid; antibacterial; sponge-derived fungus; Aspergillus sp. bisabolane-type sesquiterpenoid; antibacterial; sponge-derived fungus; Aspergillus sp.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Li, D.; Xu, Y.; Shao, C.-L.; Yang, R.-Y.; Zheng, C.-J.; Chen, Y.-Y.; Fu, X.-M.; Qian, P.-Y.; She, Z.-G.; Voogd, N.J.; Wang, C.-Y. Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.. Mar. Drugs 2012, 10, 234-241.

AMA Style

Li D, Xu Y, Shao C-L, Yang R-Y, Zheng C-J, Chen Y-Y, Fu X-M, Qian P-Y, She Z-G, Voogd NJ, Wang C-Y. Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.. Marine Drugs. 2012; 10(1):234-241.

Chicago/Turabian Style

Li, Dan; Xu, Ying; Shao, Chang-Lun; Yang, Rui-Yun; Zheng, Cai-Juan; Chen, Yi-Yan; Fu, Xiu-Mei; Qian, Pei-Yuan; She, Zhi-Gang; Voogd, Nicole J. de; Wang, Chang-Yun. 2012. "Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.." Mar. Drugs 10, no. 1: 234-241.


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