To Treat or Not to Treat Subclinical Hypothyroidism, What Is the Evidence?
Round 1
Reviewer 1 Report
The manuscript raises extremely interesting matter. Within its field of specialization, the topic is very important.
The article is very substantial and useful. The authors very precisely described the topic of subclinical hypothyroidism and controversies concerning the quality of treatment, providing new information. It is properly written.
There was a careful and comprehensive analysis of previous literature.
References were prepared very carefully and accurately.
There are not any grammatical and typographical errors.
Author Response
Thank you very much for careful reading of our manuscript and very positive comments!
Reviewer 2 Report
Thank you and congratulation for the nice work.
I have a question and that is needed to be on the manuscript.
Are there any differences between countries of high iodine intake and low iodine intake? People of low iodine intake countries can be recommended to have more iodine and for the opposite cases to have less iodine intake, for example.
Author Response
Thank you!
It is correct that iodine levels in the population can affect thyroid hormone levels and also the spectre of thyroid disease.
We know add, page 4: Also in instances of iodine excess TSH may be low or increased, with elevated peripheral hormones, indicating an increased risk for hypothyroidism in iodine-sufficient populations.
