4,7-Dimethoxy-6-propyl-2H-1,3-benzodioxole-5-carbaldehyde
Round 1
Reviewer 1 Report
Manuscript presented by Dmitry V. Tsyganov and Victor V. Semenov shows a short note study about a synthesis of 4,7-dimethoxy-6-propyl-2H-1,3-benzodioxole-5-carbaldehyde. The topic is very important due to potential biological application of this class of organic compounds. Thanks to the Authors for conducting this intriguing study.
An already well written and prepared manuscript. Easy to read and follow. I recommend the article to publish in Molbank but first the paper should be corrected. My decision – reconsider after major revision. Comments to be considered, in order to further improve the manuscript quality:
(1) Please clearly define which compound is synthesized for the first time (new connection) or only method of synthesis compound is new. If the compound is not new connection, provide appropriate references in order to comparison of compound characteristics such as melting point. Please put this information in the introduction section.
(2) Please add a description to the scheme and cite its in main text.
(3) On the scheme, clearly mark the part of this research done in this work. Consider adding a border or colour to separate from the introduction thread.
(4) Based on spectral analyses, please discuss the structure of the obtained connection.
(5) Please add full information (with details) about the reaction method monitoring (e.g. for TLC please add information about eluent and its ration).
(6) Into the supporting material the Authors should also add MS spectra.
(7) Consider add full information about synthesized connection (IR spectra also).
(8) The Authors have to add a conclusion part.
(9) Superscripts and subscripts as well as commas and dots should be checked and correct (see e.g. CH2Cl2, 13C, 1H-NMR). Avoid extra or lack of spaces and enters. Remove unnecessary capital letters in the text. Correct in whole manuscript.
(10) Standardize designations, e.g. methyl group is Me or CH3.
(11) In order to show that the topic of presented manuscript is proper for the publication in MOLBANK please include into reference other publications of this journal.
(12) The Reference style does not match this journal. Correct it.
(13) The English should be improved. Please use British English in the manuscript.
The English should be improved. Please use British English in the manuscript.
Author Response
Dear Editor
Here is the our reply to reviews to each remark:
- Please clearly define which compound is synthesized for the first time (new connection) or only method of synthesis compound is new. If the compound is not new connection, provide appropriate references in order to comparison of compound characteristics such as melting point. Please put this information in the introduction section.
Compound 6 is new, but we used literature procedure
- Please add a description to the scheme and cite its in main text.
The scheme was corrected and description explanation text added..
(3) On the scheme, clearly mark the part of this research done in this work. Consider adding a border or colour to separate from the introduction thread.
In the diagram, I marked in red the molecule obtained in the article and I indicated links to the synthesis of starting molecules. Green color marked target molecules in the future
- Based on spectral analyses, please discuss the structure of the obtained connection.
Discussion was added
- Please add full information (with details) about the reaction method monitoring (e.g. for TLC please add information about eluent and its ration).
- We do not need TLC monitoring because reaction is too fast and final product is stable in reaction mixture.
(5) Into the supporting material the Authors should also add MS spectra.
Ms-spectra was added to supplement
(6) Consider add full information about synthesized connection (IR spectra also).
IR-spectra was added to supplement
(7) The Authors have to add a conclusion part.
Conclusion was added
(9) Superscripts and subscripts as well as commas and dots should be checked and correct (see e.g. CH2Cl2, 13C, 1H-NMR). Avoid extra or lack of spaces and enters. Remove unnecessary capital letters in the text. Correct in whole manuscript.
corrected
(10) Standardize designations, e.g. methyl group is Me or CH3.
corrected
(11) In order to show that the topic of presented manuscript is proper for the publication in MOLBANK please include into reference other publications of this journal.
We published out paper for the first time in this Journal
(12) The Reference style does not match this journal. Correct it.
Reference style corrected
(13) The English should be improved. Please use British English in the manuscript.
Comments on the Quality of English Language
English was corrected to British style and mark in text by yellow
The English should be improved. Please use British English in the manuscript.
Victor Semenov
Round 2
Reviewer 1 Report
1. Please add the information provided in the review responses to manuscript eg. "Compound 6 is new, but we used literature procedure" ect.
2. A full discussion of NMR and IR analysis is necessary.
Author Response
Point1: Please clearly define which compound is synthesized for the first time (new connection) or only method of synthesis compound is new. If the compound is not new connection, provide appropriate references in order to comparison of compound characteristics such as melting point. Please put this information in the introduction section.
Response 1: Compound 6 is synthesized for the first time, we marked it in red in the scheme.
For the obtaining 6 we used previously developped our procedure.
Point 2: A full discussion of NMR and IR analysis is necessary.
Response 2: The IR spectrum shows a clear band of the carbonyl group (1609, 1674 cm-1). The 1Н and 13С spectra of compound 6 contain the aldehyde group (10.25 and 189.8 ppm, respectively), as well as all the corresponding signals of the methoxy, methylenedioxy, and propyl groups are assigned in the experiment.
Victor Semenov
