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Molbank 2014, 2014(1), M814; doi:10.3390/M814

2-{(E)-2-[(3E)-2-Chloro-3-{(2E)-2-[1,1-dimethyl-3-(3-phenylpropyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene]-ethylidene}cyclohex-1-en-1-yl]ethenyl}-1,1-dimethyl-3-(3-phenylpropyl)-1H-benzo[e]indolium Iodide

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA
Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA
Author to whom correspondence should be addressed.
Received: 20 December 2013 / Accepted: 22 January 2014 / Published: 30 January 2014
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In four synthetic steps we successfully prepared a red-shifted heptamethine cyanine dye (λmax = 825 nm in methanol) that could be very useful for biochemists and bioanalytical chemists for probing lipophilic environments, including the hydrophobic pockets of enzymes. The heptamethine dye structure was characterized by various spectroscopic techniques including 1H-NMR, 13C-NMR and high-resolution accurate mass spectroscopy (HRMS). We have also shown the hydrophobicity spectrally by varying methanol/water ratios and observing corresponding absorbance and fluorescence spectral changes.
Keywords: Hydrophobicity; carbocyanine; near-infrared; fluorescence; absorption; Vilsmeier-Haack reagent Hydrophobicity; carbocyanine; near-infrared; fluorescence; absorption; Vilsmeier-Haack reagent

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Owens, E.A.; Tawney, J.G.; Henary, M.M. 2-{(E)-2-[(3E)-2-Chloro-3-{(2E)-2-[1,1-dimethyl-3-(3-phenylpropyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene]-ethylidene}cyclohex-1-en-1-yl]ethenyl}-1,1-dimethyl-3-(3-phenylpropyl)-1H-benzo[e]indolium Iodide. Molbank 2014, 2014, M814.

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