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Molbank 2013, 2013(4), M811; doi:10.3390/M811

Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate

1
Department of Chemistry, Jordan University of Science and Technology, Irbid 22110, Jordan
2
College of Applied Medical Sciences-Al Ahsa, King Saud bin Abdulaziz University for Health Sciences, Al-Ahsa 31982, Kingdom of Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 25 October 2013 / Accepted: 9 December 2013 / Published: 12 December 2013

Abstract

A simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon heating in DMF in the presence of FeCl3 affords the title compound. The structure of the title compound was established on the basis of 1H-NMR, 13C-NMR and mass spectral data.
Keywords: benzo[e][1,4]diazepine; ferric chloride; cyclization benzo[e][1,4]diazepine; ferric chloride; cyclization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Said, N.H.; Al-Sghair, A.M. Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate. Molbank 2013, 2013, M811.

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