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Molbank 2013, 2013(4), M811; doi:10.3390/M811
Short Note

Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate

1,2,*  and 1
1 Department of Chemistry, Jordan University of Science and Technology, Irbid 22110, Jordan 2 College of Applied Medical Sciences-Al Ahsa, King Saud bin Abdulaziz University for Health Sciences, Al-Ahsa 31982, Kingdom of Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 25 October 2013 / Accepted: 9 December 2013 / Published: 12 December 2013
Download PDF [212 KB, 16 December 2013; original version 12 December 2013]


A simple route for synthesis of ethyl 2-(3-methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate is developed. The present work involves condensation of 2-(2-nitrobenzamido)propanoic acid with ethyl anthranillate followed by the H2/Pd/C reduction to give the amino ester which upon heating in DMF in the presence of FeCl3 affords the title compound. The structure of the title compound was established on the basis of 1H-NMR, 13C-NMR and mass spectral data.
Keywords: benzo[e][1,4]diazepine; ferric chloride; cyclization benzo[e][1,4]diazepine; ferric chloride; cyclization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Al-Said, N.H.; Al-Sghair, A.M. Ethyl 2-(3-Methyl-5-oxo-4,5-dihydro-3H-benzo[e][1,4]diazepin-2-ylamino)benzoate. Molbank 2013, 2013, M811.

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