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Molbank 2013, 2013(4), M808; doi:10.3390/M808
Short Note

6-[5-Chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine

1, 1,* , 1 and 2
1 Center for Advanced Materials, Department of Chemistry, Tumkur University, Tumkur-572103, Karnataka, India 2 Tadimety Aromatics Pvt. Ltd, Hirehalli Industrial Area, Tumkur-572168, India
* Author to whom correspondence should be addressed.
Received: 10 July 2013 / Accepted: 17 September 2013 / Published: 25 September 2013
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Abstract

Suzuki coupling reaction of 5-fluoro-6-methylpyridin-2-ylboronic acid (1) with 4-chloro-2-iodo-1-(trifluoromethyl)benzene (2) in the presence of dikis and K2CO3 produce C-C coupled new title compound 6-(5-chloro-2-(trifluoromethyl)phenyl)-3-fluoro-2-methylpyridine (3). The structure of the newly synthesized compound has been confirmed by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.
Keywords: Suzuki coupling; 5-fluoro-6-methylpyridin-2-ylboronic acid; 4-chloro-2-iodo-1-(trifluoromethyl)benzene; bis(triphenylphosphine)palladium(II) dichloride (dikis); 1,4-dioxane Suzuki coupling; 5-fluoro-6-methylpyridin-2-ylboronic acid; 4-chloro-2-iodo-1-(trifluoromethyl)benzene; bis(triphenylphosphine)palladium(II) dichloride (dikis); 1,4-dioxane
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Manojkumar, K.E.; Sreenivasa, S.; Nadigar, M.R.; Harikrishna, T. 6-[5-Chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine. Molbank 2013, 2013, M808.

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