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Center for Advanced Materials, Department of Chemistry, Tumkur University, Tumkur-572103, Karnataka, India
Tadimety Aromatics Pvt. Ltd, Hirehalli Industrial Area, Tumkur-572168, India
* Author to whom correspondence should be addressed.
Received: 10 July 2013; Accepted: 17 September 2013 / Published: 25 September 2013
Abstract: Suzuki coupling reaction of 5-fluoro-6-methylpyridin-2-ylboronic acid (1) with 4-chloro-2-iodo-1-(trifluoromethyl)benzene (2) in the presence of dikis and K2CO3 produce C-C coupled new title compound 6-(5-chloro-2-(trifluoromethyl)phenyl)-3-fluoro-2-methylpyridine (3). The structure of the newly synthesized compound has been confirmed by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis.
Keywords: Suzuki coupling; 5-fluoro-6-methylpyridin-2-ylboronic acid; 4-chloro-2-iodo-1-(trifluoromethyl)benzene; bis(triphenylphosphine)palladium(II) dichloride (dikis); 1,4-dioxane
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Manojkumar, K.E.; Sreenivasa, S.; Nadigar, M.R.; Harikrishna, T. 6-[5-Chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine. Molbank 2013, 2013, M808.
Manojkumar KE, Sreenivasa S, Nadigar MR, Harikrishna T. 6-[5-Chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine. Molbank. 2013; 2013(4):M808.
Manojkumar, Karikere E.; Sreenivasa, Swamy; Nadigar, Mohan R.; Harikrishna, Tadimety. 2013. "6-[5-Chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine." Molbank 2013, no. 4: M808.