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• Srinivasan, R
• Narayana, B
• Samshuddin, S
• Sarojini, B
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• Narayana, B
• Samshuddin, S
• Sarojini, B
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• Narayana, B
• Samshuddin, S
• Sarojini, B

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Molbank 2012, 2012(3), M769; doi:10.3390/M769

Short Note

N-(3,4-Dimethoxyphenyl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-1-carboxamide Hydrochloride

Rajagopalan Srinivasan ^1,2 , Badiadka Narayana ^1,* , Seranthimata Samshuddin ¹  and Balladka Kunhanna Sarojini ³

¹ Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India ² Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India ³ Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India

* Author to whom correspondence should be addressed.

Received: 29 May 2012 / Accepted: 3 August 2012 / Published: 8 August 2012

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Abstract: A simple and novel route for synthesis of new spirocyclic amide derivative is developed. The present work involves the oxidative cleavage of tert-butyl 1-(furan-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate 1 followed by the amine coupling and deprotection of Boc.

Keywords: spirocyclic; pyrazolone; oxidation; amide

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