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Molbank 2011, 2011(4), M742; doi:10.3390/M742

Short Note

3-[1-(4-Methylphenyl)-3-oxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl]propanoic Acid

Ferenc Csende ^1,* , József Jekő ²  and Andrea Porkoláb ¹

¹ Taxus Research Laboratory, Bocskai u. 22, H-4080 Hajdúnánás, Hungary ² Department of Chemistry, College of Nyíregyháza, H-4400 Nyíregyháza, Sóstói st. 31/B, Hungary

* Author to whom correspondence should be addressed.

Received: 3 August 2011 / Accepted: 8 November 2011 / Published: 10 November 2011

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Abstract: A simple solvent-free synthesis of 3-[1-(4-methylphenyl)-3-oxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl]propanoic acid 3 was achieved by fusion of cis-2-[(4-methylphenyl)carbonyl]cyclohexanecarboxylic acid 1 with 3-aminopropanoic acid 2. The structure of this new compound was confirmed by elemental analysis, IR, EI-MS, ¹H-NMR and ¹³C-NMR spectral data.

Keywords: isoindolone; 4-oxocarboxylic acid; β-aminoacid

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