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Molbank 2011, 2011(2), M728; doi:10.3390/M728
Short Note

8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one

 and *
Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus
* Author to whom correspondence should be addressed.
Received: 10 May 2011 / Accepted: 24 May 2011 / Published: 30 May 2011
Download PDF [182 KB, uploaded 30 May 2011]

Abstract

8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.
Keywords: soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Berezin, A.A.; Koutentis, P.A. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank 2011, 2011, M728.

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