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Molbank 2011, 2011(2), M728; doi:10.3390/M728


Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus
Author to whom correspondence should be addressed.
Received: 10 May 2011 / Accepted: 24 May 2011 / Published: 30 May 2011
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8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.
Keywords: soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Berezin, A.A.; Koutentis, P.A. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank 2011, 2011, M728.

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