Next Article in Journal
1,3-Bis(pyren-1-yl)imidazolium chloride (IPyr·HCl)
Previous Article in Journal
(2E)-3-(4-Dimethylaminophenyl)-1-(2,5-dimethylfuran-3-yl)-prop-2-en-1-one
Molbank 2011, 2011(2), M728; doi:10.3390/M728
Short Note

8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one

 and *
Received: 10 May 2011 / Accepted: 24 May 2011 / Published: 30 May 2011
Download PDF [182 KB, uploaded 30 May 2011]

Abstract

8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.
Keywords: soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplements

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Berezin, A.A.; Koutentis, P.A. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank 2011, 2011, M728.

View more citation formats

Article Metrics

Comments

Citing Articles

[Return to top]
Molbank EISSN 1422-8599 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert