Molbank 2011, 2011(2), M728; doi:10.3390/M728
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Received: 10 May 2011; Accepted: 24 May 2011 / Published: 30 May 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.
Keywords: soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling
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MDPI and ACS Style

Berezin, A.A.; Koutentis, P.A. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank 2011, 2011, M728.

AMA Style

Berezin AA, Koutentis PA. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank. 2011; 2011(2):M728.

Chicago/Turabian Style

Berezin, Andrey A.; Koutentis, Panayiotis A. 2011. "8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one." Molbank 2011, no. 2: M728.

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