1-[4-[Bis(2-chloroethyl)amino]benzyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-pyrroles, Part II)

doi:10.3390/M654

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Molbank 2010, 2010(1), M654; doi:10.3390/M654

Short Note

1-[4-[Bis(2-chloroethyl)amino]benzyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-pyrroles, Part II)

Helmut Spreitzer* and Christiane Puschmann

Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstraße 14, A- 1090 Vienna, Austria

* Author to whom correspondence should be addressed.

Received: 4 December 2009 / Accepted: 26 January 2010 / Published: 29 January 2010

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Abstract: A bis(chloroethyl)amine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.

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MDPI and ACS Style

Spreitzer, H.; Puschmann, C. 1-[4-[Bis(2-chloroethyl)amino]benzyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-pyrroles, Part II). Molbank 2010, 2010, M654.

AMA Style

Spreitzer H, Puschmann C. 1-[4-[Bis(2-chloroethyl)amino]benzyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-pyrroles, Part II). Molbank. 2010; 2010(1):M654.

Chicago/Turabian Style

Spreitzer, Helmut; Puschmann, Christiane. 2010. "1-[4-[Bis(2-chloroethyl)amino]benzyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-pyrroles, Part II)." Molbank 2010, no. 1: M654.

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