Determination of the Absolute Configurations of (+)-N-((3S)-3- {[(4-methylphenyl)sulfonyl]amino}-1-oxaspiro[4.5]deca-6,9- dien-2,8-dion-7-yl) Acetamide and Benzamide

doi:10.3390/M579

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Molbank 2008, 2008(3), M579; doi:10.3390/M579

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Determination of the Absolute Configurations of (+)-N-((3S)-3- {[(4-methylphenyl)sulfonyl]amino}-1-oxaspiro[4.5]deca-6,9- dien-2,8-dion-7-yl) Acetamide and Benzamide

Guy L. Plourde^1,* , Lyndia M. Susag¹ and David G. Dick²

¹ University of Northern British Columbia, Department of Chemistry, 3333 University Way, Prince George, British Columbia, V2N 4Z9, Canada ² College of the Rockies, University Studies (Chemistry), Box 8500, Cranbrook, British Columbia, V1C 5L7, Canada

* Author to whom correspondence should be addressed.

Received: 18 September 2008 / Accepted: 3 November 2008 / Published: 7 November 2008

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Abstract: We recently reported the asymmetric synthesis of the two title compounds without the configurational assignments of the newly formed chiral spirocarbons. We now wish to report that both compounds have a (R)-configuration at the spirocarbon based on 1D and 2D nuclear Overhauser enhancement (nOe) experiments.

Keywords: Spiroannulation; stereochemistry; nOe; NMR; absolute configuration

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MDPI and ACS Style

Plourde, G.L.; Susag, L.M.; Dick, D.G. Determination of the Absolute Configurations of (+)-N-((3S)-3- {[(4-methylphenyl)sulfonyl]amino}-1-oxaspiro[4.5]deca-6,9- dien-2,8-dion-7-yl) Acetamide and Benzamide. Molbank 2008, 2008, M579.

AMA Style

Plourde GL, Susag LM, Dick DG. Determination of the Absolute Configurations of (+)-N-((3S)-3- {[(4-methylphenyl)sulfonyl]amino}-1-oxaspiro[4.5]deca-6,9- dien-2,8-dion-7-yl) Acetamide and Benzamide. Molbank. 2008; 2008(3):M579.

Chicago/Turabian Style

Plourde, Guy L.; Susag, Lyndia M.; Dick, David G. 2008. "Determination of the Absolute Configurations of (+)-N-((3S)-3- {[(4-methylphenyl)sulfonyl]amino}-1-oxaspiro[4.5]deca-6,9- dien-2,8-dion-7-yl) Acetamide and Benzamide." Molbank 2008, no. 3: M579.

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