Next Article in Journal
Antiproliferative Activity of β-Hydroxy-β-Arylalkanoic Acids
Next Article in Special Issue
Effects of Acetazolamide Combined with or without NaHCO3 on Suppressing Neoplasm Growth, Metastasis and Aquaporin-1 (AQP1) Protein Expression
Previous Article in Journal / Special Issue
Results from the Use of Molecular Descriptors Family on Structure Property/Activity Relationships
Int. J. Mol. Sci. 2007, 8(3), 204-213; doi:10.3390/i8030204

Expression of VDAC Regulated by Extracts of Limonium sinense Ktze root Against CCl4-induced Liver Damage

1,* , 2,* , 3, 3, 3, 3, 3 and 3
1 Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers College, Yancheng, 224002, P.R.China. 2 School of Pharmacy, Jiangsu University, Zhenjiang, 212013 P.R.China 3 School of Medicine, Nanjing University, 22 Hankou Road, Nanjing 210093, China
* Authors to whom correspondence should be addressed.
Received: 14 December 2006 / Accepted: 26 February 2007 / Published: 9 March 2007
(This article belongs to the Special Issue Interaction of Biological Molecules)
View Full-Text   |   Download PDF [149 KB, uploaded 19 June 2014]   |   Browse Figures


The expression of mitochondrial voltage-dependent anion channels (VDAC) mayunderlie the protective effects of Limonium sinense (Girard) Ktze root extracts (LSE) againstcarbon tetrachloride-induced liver damage. Pretreatment of mice with 100 mg/kg, 200mg/kg or 400 mg/kg LSE significantly blocked the carbon tetrachloride-induced increase inboth serum aspartate aminotransferase (sAST) and serum alanine aminotransferase (sALT)levels. Ultrastructural observations by electron microscope confirmed hepatoprotection,showing decreased nuclear condensation, ameliorated mitochondrial fragmentation of thecristae and less lipid deposition. Pretreatment with LSE prevented the decrease of thedisruption of mitochondrial membrane potential (15.3%) observed in the liver of the carbontetrachloride-insulted mice, further demonstrating the mitochondrial protection. In addition,LSE treatment (100-400 mg/kg) significantly increased both transcription and translation ofVDAC. The above data suggests that LSE mitigates the damage to liver mitochondriainduced by carbon tetrachloride, possibly through regulation of mitochondrial VDAC, one ofthe most important proteins in the mitochondrial outer membrane.
Keywords: Limonium sinense (Girard) Ktze; liver; mitochondria; voltage-dependent anion channels Limonium sinense (Girard) Ktze; liver; mitochondria; voltage-dependent anion channels
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Tang, X.; Ga, J.; Chen, J.; Xu, L.; Tang, Y.; Dou, H.; Yu, W.; Zhao, X. Expression of VDAC Regulated by Extracts of Limonium sinense Ktze root Against CCl4-induced Liver Damage. Int. J. Mol. Sci. 2007, 8, 204-213.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert