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Int. J. Mol. Sci. 2005, 6(1), 87-96; doi:10.3390/i6010087
Article

Application of the Extended Grunwald-Winstein Equation to Solvolyses of n-Propyl Chloroformate

1,* , 1 and 2,*
Received: 30 November 2004 / Accepted: 10 December 2004 / Published: 31 January 2005
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Abstract

Application of the extended Grunwald-Winstein equation to solvolyses of n-propyl chloroformate in a variety of pure and binary solvents indicates an addition-elimination pathway in the majority of the solvents but an ionization pathway in the solvents of highest ionizing power and lowest nucleophilicity. For methanolysis, a solvent deuterium isotope effect of 2.17 is compatible with the incorporation of general-base catalysis into the substitution process. Activation parameters are consistent with the duality of mechanism. Very modest positive salt effects are observed on adding chloride or bromide salts to the ethanolysis.
Keywords: n-Propyl chloroformate; addition-elimination; ionization; solvent isotope effect; Grunwald-Winstein equation n-Propyl chloroformate; addition-elimination; ionization; solvent isotope effect; Grunwald-Winstein equation
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Kyong, J.B.; Won, H.; Kevill, D.N. Application of the Extended Grunwald-Winstein Equation to Solvolyses of n-Propyl Chloroformate. Int. J. Mol. Sci. 2005, 6, 87-96.

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