Hyperthermia of Magnetically Soft-Soft Core-Shell Ferrite Nanoparticles
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structural and Magnetic Characterization of the MnFe2O4 Nanoparticle Seeds
2.2. Structural and Magnetic Characterization of the MnFe2O4-Fe3O4 Core-Shell Nanoparticles
2.3. Magnetic Measurements of the MnFe2O4-Fe3O4 Core-Shell Nanoparticles
2.4. Magnetic Hyperthermia Studies of the Core-Shell Nanoparticles in Phantom Agar Gel
2.5. Cytotoxicity Assay
2.6. Apoptosis Assay
3. Materials and Methods
3.1. Synthesis of the MnFe2O4 Nanoparticle
3.2. Synthesis of the Core-Shell Nanoparticles
3.3. Characterization of the Nanoparticles
3.4. Cell Culture
3.5. Cytotoxicity Assay
3.6. Apoptosis Assay
3.7. Magnetothermal Measurements
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nanoparticles | Particle Sizes (nm) | Lattice Constant (Å) |
---|---|---|
MnFe2O4 | 5.4 | 8.4297 |
S1-core-shell | 9.6 | 8.3844 |
S2-core-shell | 11.7 | 8.4010 |
Particles | (311) Peak Position |
---|---|
Fe3O4 | 35.5723 ± 0.0014 |
MnFe2O4 | 34.9869 ± 0.0001 |
Mixture | 35.0461 ± 0.0019 |
S1-core-shell | 35.4629 ± 0.0037 |
S2-core-shell | 35.4029 ± 0.0019 |
Compositions | Average Sizes from the XRD (nm) | Average TEM Sizes (nm) | Shell Thickness (nm) | MS (emu/g) | Keff 103 J/m3 | SAR (W/g) at 495.25 kHz and 350 G |
---|---|---|---|---|---|---|
MnFe2O4 seeds | 5.4 | 5.0 ± 1.2 | 39.07 | 150.6 | ||
S1 [Fe3O4(MnFe2O4)] | 9.5 | 9.1 ± 2.2 | 4.1 | 70.40 | 1.946 | 311.8 |
S2 [Fe3O4(MnFe2O4)] | 11.7 | 10.7 ± 1.3 | 5.7 | 69.90 | 2.216 | 356.5 |
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Narayanaswamy, V.; Jagal, J.; Khurshid, H.; Al-Omari, I.A.; Haider, M.; Kamzin, A.S.; Obaidat, I.M.; Issa, B. Hyperthermia of Magnetically Soft-Soft Core-Shell Ferrite Nanoparticles. Int. J. Mol. Sci. 2022, 23, 14825. https://doi.org/10.3390/ijms232314825
Narayanaswamy V, Jagal J, Khurshid H, Al-Omari IA, Haider M, Kamzin AS, Obaidat IM, Issa B. Hyperthermia of Magnetically Soft-Soft Core-Shell Ferrite Nanoparticles. International Journal of Molecular Sciences. 2022; 23(23):14825. https://doi.org/10.3390/ijms232314825
Chicago/Turabian StyleNarayanaswamy, Venkatesha, Jayalakshmi Jagal, Hafsa Khurshid, Imaddin A. Al-Omari, Mohamed Haider, Alexander S. Kamzin, Ihab M. Obaidat, and Bashar Issa. 2022. "Hyperthermia of Magnetically Soft-Soft Core-Shell Ferrite Nanoparticles" International Journal of Molecular Sciences 23, no. 23: 14825. https://doi.org/10.3390/ijms232314825