Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite
Abstract
:1. Introduction
2. Results
2.1. Reduced Stress-Shielding Effect through BG Doping
2.2. Highest Bone Volume Fraction in the Optimal Ti-6Al-4V Doped with BG
2.3. Reliable TXM Imaging Technique for Bone Characterization
2.4. Rapid Bone Graft Incorporation in Optimal Ti-6Al-4V Doped with BG
2.5. Most Successful Bone Remodeling with Optimal Ti-6Al-4V Doped with BG
3. Discussion
4. Materials and Methods
4.1. Preparation of Pedicle Screw Implants
4.2. Preparation of Spine Specimens
4.3. Tensile Test
4.4. X-ray Micro-Computed Tomography
4.5. Transmission X-ray Microscopy
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
Ti-6Al-4V | Titanium-aluminum-vanadium |
BG | Bioactive glass |
Ti | Titanium |
HA | Hydroxyapatite |
3D | Three-dimensional |
SLM | Selective laser melting |
µCT | X-ray micro-computed tomography |
TXM | Transmission X-ray microscopy |
S-S | Stress–strain |
IACUC | Institutional Animal Care and Use Committee |
TMU | Taipei Medical University |
SNS | Spallation Neutron Source |
ORNL | Oak Ridge National Laboratory |
BL | Beamline |
NSRRC | National Synchrotron Radiation Research Center |
2D | Two-dimensional |
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Lam, T.-N.; Trinh, M.-G.; Huang, C.-C.; Kung, P.-C.; Huang, W.-C.; Chang, W.; Amalia, L.; Chin, H.-H.; Tsou, N.-T.; Shih, S.-J.; et al. Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite. Int. J. Mol. Sci. 2020, 21, 7438. https://doi.org/10.3390/ijms21207438
Lam T-N, Trinh M-G, Huang C-C, Kung P-C, Huang W-C, Chang W, Amalia L, Chin H-H, Tsou N-T, Shih S-J, et al. Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite. International Journal of Molecular Sciences. 2020; 21(20):7438. https://doi.org/10.3390/ijms21207438
Chicago/Turabian StyleLam, Tu-Ngoc, Minh-Giam Trinh, Chih-Chieh Huang, Pei-Ching Kung, Wei-Chin Huang, Wei Chang, Lia Amalia, Hsu-Hsuan Chin, Nien-Ti Tsou, Shao-Ju Shih, and et al. 2020. "Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite" International Journal of Molecular Sciences 21, no. 20: 7438. https://doi.org/10.3390/ijms21207438