Adiponectin as Link Factor between Adipose Tissue and Cancer
Abstract
:1. Introduction
2. Adiponectin Structure and Function
3. Adiponectin Signaling Pathways
4. Adipose Tissue, Adiponectin and Low Chronic Inflammation
5. Adiponectin in Cancer
5.1. Adiponectin in Breast Cancer
5.2. Adiponectin in Lung Cancer
5.3. Adiponectin in Colon Cancer
5.4. Adiponectin in Thyroid Cancer
5.5. Adiponectin in Other Cancers
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AdipoR | Adiponectin receptor |
AMPK | 5’-adenosine monophosphate-activated protein kinase |
APN | Adiponectin |
BC | Breast cancer |
BMI | Body Mass Index |
COX-2 | Cyclooxygenase |
CRC | Colorectal cancer |
cPLA2 | Cytosolic phospholipase A2 |
CREB | cAMP response element-binding protein |
ER | Estrogen receptor |
ERK1/2 | Extracellular signal-regulated protein kinases 1 and 2 |
fT4 | Free thyroxine |
HFD | High-fat diet |
IGF-1 | Insulin-like growth factor 1 |
IL-10 | Interleukin-10 |
IL-6 | Interleukin-6 |
IL-8 | Interleukin-8 |
JAK2 | Janus kinase 2 |
MAPK | Mitogen-activated protein kinase |
MCP-1 | Monocyte chemoattractant protein 1 |
mTOR | Mammalian target of rapamycin |
NF-κB | Nuclear factor-κB |
PI3K | Phosphatidylinositol-4,5-bisphosphate 3-kinase |
PPAR | Peroxisome proliferator-activated receptors |
PP2A | Protein phosphatase 2 A |
pRb | Phosphorylated retinoblastoma protein |
ROS | Reactive oxygen species |
STAT3 | Signal transducer and activator of transcription 3 |
TC | Thyroid cancer |
TNF-α | Tumor necrosis factor-α |
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Di Zazzo, E.; Polito, R.; Bartollino, S.; Nigro, E.; Porcile, C.; Bianco, A.; Daniele, A.; Moncharmont, B. Adiponectin as Link Factor between Adipose Tissue and Cancer. Int. J. Mol. Sci. 2019, 20, 839. https://doi.org/10.3390/ijms20040839
Di Zazzo E, Polito R, Bartollino S, Nigro E, Porcile C, Bianco A, Daniele A, Moncharmont B. Adiponectin as Link Factor between Adipose Tissue and Cancer. International Journal of Molecular Sciences. 2019; 20(4):839. https://doi.org/10.3390/ijms20040839
Chicago/Turabian StyleDi Zazzo, Erika, Rita Polito, Silvia Bartollino, Ersilia Nigro, Carola Porcile, Andrea Bianco, Aurora Daniele, and Bruno Moncharmont. 2019. "Adiponectin as Link Factor between Adipose Tissue and Cancer" International Journal of Molecular Sciences 20, no. 4: 839. https://doi.org/10.3390/ijms20040839