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Article
Peer-Review Record

Farnesiferol C Induces Apoptosis in Chronic Myelogenous Leukemia Cells as an Imatinib Sensitizer via Caspase Activation and HDAC (Histone Deacetylase) Inactivation

Int. J. Mol. Sci. 2019, 20(22), 5535; https://doi.org/10.3390/ijms20225535
by Ji Hoon Jung, Ji Eon Park, Deok Yong Sim, Eunji Im, Woon Yi Park, Duckgue Lee, Bum-Sang Shim and Sung-Hoon Kim *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(22), 5535; https://doi.org/10.3390/ijms20225535
Submission received: 4 October 2019 / Revised: 30 October 2019 / Accepted: 5 November 2019 / Published: 6 November 2019
(This article belongs to the Special Issue Bioactive Phytochemicals for Cancer Prevention and Treatment)

Round 1

Reviewer 1 Report

Thanks for addressing all comments. 

Author Response

Thank you for kind advice.

Reviewer 2 Report

To rule out that the findings are merely correlative, genetic manipulation of HDAC is absolutely necessary. 

 

Author Response

Thanks for your critical comments.

We performed the Western blotting after transfection with HDAC1 overexpression plasmid and bar graph was drawn by using density values in Figure 5.

Round 2

Reviewer 2 Report

Revision is satisfactory

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