Substituent Effects on the Radical Scavenging Activity of Isoflavonoid

Round  1

Reviewer 1 Report

This work by Da-Fu Chen et al. describes the investigation, by the DFT Method, of the effect of various substituents, on reaction enthalpies related to hydrogen atom transfer, single electron transfer-proton transfer, and sequential proton loss electron transfer mechanisms, of the derivatives of 4’,5,7-trihydroxyisoflavone and 4’,5,7-71 trihydroxyisoflavanone covering the electron-withdrawing groups and electron-donating groups placed at the C2 position, . The results are well supported by experimental facts and the manuscript could be accepted as its.

Author Response

Thanks very much.

Reviewer 2 Report

The submitted manuscript deals with computer modeling and calculations of substituent effects on isoflavonoid antioxidant activities. The authors investigated various parameters which can affect reactions of isoflavonoid molecules with various types of reactive species.

The authors used adequate methods. The results are properly discussed. Furthermore, the authors cited the most important references.

Minor issue: Delete the text of lines 279 – 280 (“This section is not mandatory, but can be added to the manuscript if the discussion is unusually long or complex.”).

Since I found no serious mistakes I recommend the manuscript for publication.

Author Response

Thanks for your reminding. We have deleted the text of the lines in the revised manuscript.